Rb Polyclonal Antibody, 100ul[BT-AP07694] Electrophoresis & Labeling transferring phosphorus-containing groups and protein

transferring phosphorus-containing groups and protein tyrosine kinase activity

test samples

Two protein-coding transcripts and one non-protein coding transcript have been found for this gene

subcellular location:Seems to be excluded from nucleoli

Multiple alternatively spliced transcript variants encoding two isoforms with different length have been identified

Rb Polyclonal Antibody, 100ul[BT-AP07694] Electrophoresis & Labeling transferring phosphorus-containing groups and proteinThe protein encoded by RB1 (RB transcriptional corepressor 1) is a negative regulator of the cell cycle and was the first tumor suppressor gene found. The encoded protein also stabilizes constitutive heterochromatin to maintain the overall chromatin structure. The active, hypophosphorylated form of the protein binds transcription factor E2F1. Defects in RB1 are a cause of childhood cancer retinoblastoma (RB), bladder cancer, and osteogenic sarcoma.