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GRK2(Phospho-Tyr86) Polyclonal Antibody, 20ul Palm Micro Centrifuges Mutations in this gene are

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GRK2(Phospho-Tyr86) Polyclonal Antibody, 20ul Palm Micro Centrifuges Mutations in this gene areThe product of this gene phosphorylates the beta 2 adrenergic receptor and appears to mediate agonist specific desensitization observed at high agonist concentrations. This protein is an ubiquitous cytosolic enzyme that specifically phosphorylates the activated form of the beta adrenergic and related G protein coupled receptors. Abnormal coupling of beta adrenergic receptor to G protein is involved in the pathogenesis of the failing heart.

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Description

Mutations in this gene are associated with X-linked Alport syndrome

and expression of this gene is altered in some types of cancer

The resulting loss of 26 nt from the spliced mRNA causes a frame-shift and an isoform XBP1(S)

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The fucosyl donor for these fucosylated oligosaccharides is GDP-beta-L-fucose

GRK2(Phospho-Tyr86) Polyclonal Antibody, 20ul Palm Micro Centrifuges Mutations in this gene areThe product of this gene phosphorylates the beta 2 adrenergic receptor and appears to mediate agonist specific desensitization observed at high agonist concentrations. This protein is an ubiquitous cytosolic enzyme that specifically phosphorylates the activated form of the beta adrenergic and related G protein coupled receptors. Abnormal coupling of beta adrenergic receptor to G protein is involved in the pathogenesis of the failing heart.

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