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TLE3 Rabbit Polyclonal Antibody, 20ul Plasma Within the SAGA complex

SKU: 13327081827

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TLE3 Rabbit Polyclonal Antibody, 20ul Plasma Within the SAGA complexThis gene encodes a transcriptional co repressor protein that belongs to the transducin like enhancer family of proteins. The members of this family function in the Notch signaling pathway that regulates determination of cell fate during development. Expression of this gene has been associated with a favorable outcome to chemotherapy with taxanes for ovarian carcinoma. Alternate splicing results in multiple transcript variants. Additional

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Description

Within the SAGA complex

the full-length natures of only two have been described to date

Studies suggest that this protein could function to inhibit smooth muscle cell proliferation and migration following arterial injury

An important paralog of this gene is SERPINB12

The subcellular localization and function of this protein are modulated by post-translational modifications

TLE3 Rabbit Polyclonal Antibody, 20ul Plasma Within the SAGA complexThis gene encodes a transcriptional co repressor protein that belongs to the transducin like enhancer family of proteins. The members of this family function in the Notch signaling pathway that regulates determination of cell fate during development. Expression of this gene has been associated with a favorable outcome to chemotherapy with taxanes for ovarian carcinoma. Alternate splicing results in multiple transcript variants. Additional

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