APBB3 Rabbit Polyclonal Antibody, 20ul Electrophoresis & Labeling This gene may be involved

This gene may be involved in coronary artery disease and in the pathogenesis of sepsis

Mutations in this gene are predicted to result in neurogenic defects

In nervous system

Constitutive activation of this gene caused either by somatic mutations| or genomic duplications of regions that include this gene| have been associated with hyperplasias and adenomas of the adrenal cortex and are linked to corticotropin-independent Cushing's syndrome

which implicated the role in neurodegenerative diseases

APBB3 Rabbit Polyclonal Antibody, 20ul Electrophoresis & Labeling This gene may be involvedThe protein encoded by this gene is a member of the APBB protein family. It is found in the cytoplasm and binds to the intracellular domain of the Alzheimer's disease beta amyloid precursor protein (APP) as well as to other APP like proteins. It is thought that the protein encoded by this gene may modulate the internalization of APP. Multiple transcript variants encoding several different isoforms have been found for this gene.