FXL18 Rabbit Polyclonal Antibody, 100ul Organelle Studies COX5A (cytochrome c oxidase subunit

COX5A (cytochrome c oxidase subunit 5A) encodes the nuclear-encoded subunit Va of the human mitochondrial respiratory chain enzyme

similarity:Contains 3 C2H2-type zinc fingers

the encoded protein complexes with hypoxia-inducible factor 1alpha in the nucleus and this complex binds to hypoxia-responsive elements in enhancers and promoters of oxygen-responsive genes

Mutations in this gene are associated with multiple endocrine neoplasia type IV (MEN4)

Mutations in this gene cause hereditary sensory and autonomic neuropathy with spastic paraplegia (HSNSP)

FXL18 Rabbit Polyclonal Antibody, 100ul Organelle Studies COX5A (cytochrome c oxidase subunitThe protein encoded by this gene is a member of a family of proteins that contain an approximately 40 amino acid F box motif. This motif is important for interaction with SKP1 and for targeting some proteins for degradation. The encoded protein has been shown to control the cellular level of FBXL7 a protein that induces mitotic arrest by targeting it for polyubiquitylation and proteasomal degradation. Members of the F box protein family such as FBXL18