PGE synthase Polyclonal Antibody, 100ul Electronic Pipette Three alternatively spliced transcript variants

Three alternatively spliced transcript variants encoding the same protein have been described for CPM

The protein encoded by this gene catalyzes the conversion of 5

This protein is involved in the ubiquitination and degradation of hypoxia-inducible-factor (HIF)

and cellular pH homeostasis

It is an integral membrane protein and plays an important role in inhibiting neurotransmission by binding to the benzodiazepine receptor and opening an integral chloride channel

PGE synthase Polyclonal Antibody, 100ul Electronic Pipette Three alternatively spliced transcript variantsProstaglandin E synthase encoded by PTGES is a glutathione dependent prostaglandin E synthase. The expression of PTGES has been shown to be induced by proinflammatory cytokine interleukin 1 beta (IL1B). Its expression can also be induced by tumor suppressor protein TP53, and may be involved in TP53 induced apoptosis. Knockout studies in mice suggest that PTGES may contribute to the pathogenesis of collagen induced arthritis and mediate acute pain