SDHF1 Rabbit Polyclonal Antibody, 100ul Multiplex Immunoassays The protein localizes to the

The protein localizes to the Golgi apparatus during interphase

Alternative splicing results in multiple transcript variants

Mutations in this gene are a cause of spastic paraplegia-18 (SPG18)

and gamma subunits

At least one of these variants encodes a preproprotein that is proteolytically processed to generate the mature protein

SDHF1 Rabbit Polyclonal Antibody, 100ul Multiplex Immunoassays The protein localizes to theThe succinate dehydrogenase (SDH) complex (or complex II) of the mitochondrial respiratory chain is composed of 4 individual subunits. The protein encoded by this gene resides in the mitochondria and is essential for SDH assembly but does not physically associate with the complex in vivo. Mutations in this gene are associated with SDH defective infantile leukoencephalopathy (mitochondrial complex II deficiency).