Phospho-Akt (T308) Polyclonal Antibody, 50ul[BT-PHS00490] Reservoirs Mutations in this gene have

Mutations in this gene have been associated with a predisposition to myeloid malignancy

An important paralog of this gene is DRD4

The encoded protein is a highly specific ubiquitin iso-peptidase

and is involved in box C/D snoRNP biogenesis

|online information:Factor X entry|PTM:N- and O-glycosylated

Phospho-Akt (T308) Polyclonal Antibody, 50ul[BT-PHS00490] Reservoirs Mutations in this gene haveThe serine threonine protein kinase encoded by the AKT1 gene is catalytically inactive in serum starved primary and immortalized fibroblasts. AKT1 and the related AKT2 are activated by platelet derived growth factor. The activation is rapid and specific, and it is abrogated by mutations in the pleckstrin homology domain of AKT1. It was shown that the activation occurs through phosphatidylinositol 3 kinase. In the developing nervous system AKT is a