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This three-way comparison is more than an academic exercise

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The incidence rate of nausea in patients who receive tirzepatide was 20.43%, while the incidence rate in the comparators was 10.47%, and it was significantly higher in the tirzepatide arm than in the comparators (RR, 2.90

Summary: Current regulatory reviews by the MHRA and EMA have found no established causal link between Rybelsus (semaglutide) and mental health side effects, though some patients report mood changes during treatment