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1 Introduction Sepsis-associated encephalopathy (SAE) represents a severe complication of sepsis, defined by diffuse brain dysfunction without direct central nervous system (CNS) infection (Young et al., 1990) and the overall mortality rate remains high at 25%50%, despite advances in critical care

Sterile water: fine for single-use prep, but has no preservative, so contamination can begin within 48 to 72 hours

Less than 1 cm in greatest diameter

The dysregulation between ROS and antioxidants contributes to sepsis progression, impacting cellular function and mortality

Some people may experience mild side effects such as nausea, headache, or diarrhea