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It also helps to measure more than one outcome

Expected outcomes based on trial data: Average weight loss of 24.2% at 48 weeks (phase 2) Average weight loss of 28.7% at 68 weeks (phase 3, TRIUMPH-4) 100% of participants achieved 5% or greater weight loss 93% achieved 10% or greater 83% achieved 15% or greater Moderate weight loss protocol (8mg target) For researchers who want significant weight loss but have a lower tolerance for side effects, stopping the escalation at 8mg is a validated approach

When the skin starts to hurt, or turns a deeper purple color, doctors worry about something more serious

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According to the Hong Kong 2020-2022 Population Health Survey, 32.6% of adults aged 15 to 84 are classified as obese (BMI 25 kg/m 2 ), and 22.0% as overweight (BMI 23-25 kg/m 2 ) [1]