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Microglial and astrocytic proteins are preferentially elevated in the GCLC-KO mouse brain To uncover mechanisms leading to brain atrophy in GCLC-KO mice, we next performed a comprehensive analysis of protein expression by Liquid Chromatography-Mass spectrometry (LCMS) analysis using brain samples from 4-month-old GCLC-KO mice (Fig

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2.4 Circular dichroism (CD) spectroscopy Similar to ORD, circular dichroism (CD) is rooted in the analysis of optical activity, with CD measuring the difference in absorption of left and right circularly polarized light by a chiral molecule

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Methylmalonic aciduria cblC type with homocystinuria (MMACHC) and methylmalonic aciduria cblD type with homocystinuria (MMADHC) must work together for Cbl to be delivered to MeSe, since they have, both been demonstrated to physically interact with it