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It is worth noting that gsp-positive tumors are characterized by an increased responsivity to treatment with SS analogs, a feature up to now unexplained since no increase of SS receptors have been found in these tumors (40, 5557)

As a pioneering antibody-peptide conjugate molecule with a long half-life and dual mechanism of action, MariTide may allow for greater durability or reduce the likelihood of weight rebound after treatment stops

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Furthermore, in colorectal cancer, IGF-2 is critical for cancer stem cell formation and IGF-2 preferentially interacts with insulin receptor isoform A rather than with IGF-1R to accelerate autophagy and metabolic remodeling in colorectal cancer (55)