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This is most relevant for: Adults over 65 with baseline systolic BP below 110 mmHg Patients on multiple antihypertensives (losartan plus amlodipine plus hydrochlorothiazide, for example) People who are volume-depleted from diuretics, illness, or inadequate fluid intake For a patient whose resting BP is 135/85 on losartan 50 mg, adding glycine 3 g at bedtime poses minimal hypotension risk

Buckinx F, Landi F, Cesari M, et al

Some of that benefit is attributable to BP reduction, some to weight loss generally, some to direct cardiac effects, and some to glycemic improvement

Note that upper arm injections are generally recommended to be administered by a caregiver, per manufacturer instructions for use

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