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Signs of a severe allergic reaction (anaphylaxis) include: Skin rash, hives, or severe itching Swelling of the face, lips, tongue, or throat Difficulty breathing or wheezing A rapid heartbeat or a sudden drop in blood pressure If you ever develop swelling of the face or throat, trouble breathing, or other signs of a severe reaction after any injection, treat it as an emergency and call 911

Kuzminski AM, del Giacco EJ, Allen RH et al (1998) Effective treatment of cobalamin deficiency with oral cobalamin

Its key when patients have many vitamin deficiencies

Community oral doses (50-150 mg daily) are based on allometric scaling from mouse studies, oral bioavailability data, and several years of community trial and error

Researchers should add one compound at a time, assess tolerance, and avoid the temptation to implement complex protocols immediately