Stat5a Polyclonal Antibody, 20ul[BT-AP08639] Peptide Modification Eukaryotic release factor 3 (eRF3)

Eukaryotic release factor 3 (eRF3) has many functions in eukaryotic cells

autosomal dominant iridogoniodysgenesis anomaly

nine cadherin domains and two laminin A G-type repeats in their ectodomain

It is thought that this protein may be involved in oocyte maturation and follicular development as a homodimer or by forming heterodimers with a related protein

which interacts with the sliding DNA clamp protein PCNA

Stat5a Polyclonal Antibody, 20ul[BT-AP08639] Peptide Modification Eukaryotic release factor 3 (eRF3)Stat5 is activated in response to a wide variety of ligands including IL 2, GM CSF, growth hormone and prolactin. Phosphorylation at Tyr694 is obligatory for Stat5 activation. This phosphorylation is mediated by Src upon erythropoietin stimulation. Stat5 is constitutively active in some leukemic cell types. Phosphorylated Stat5 is found in some endothelial cells treated with IL 3, which suggests its involvement in angiogenesis and cell motility.