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In a 2001 study published in Endocrinology , Heffernan and colleagues reported that chronic AOD-9604 administration reduced body weight gain, decreased adipose tissue mass, and increased fat oxidation in obese mice without altering IGF-1 levels or glucose metabolism effects that were abolished in beta3 adrenergic receptor (3-AR) knockout mice, implicating 3-AR signaling as the mechanism of action [1]

In contrast, SQ shots are almost painless, carry no risk of nerve injury, and are effective for delivering B12

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More clinical research should investigate the effectiveness across different patient conditions, but the existing evidence suggests the treatments are generally safe, well tolerated, and worth trying for those struggling with chronic pain or steroid side effects

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