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Comparison of the exendin-4 and exendin-P5 bound (PDB 6B3J) structures revealed similarities in their ECD location and greater similarities of the backbone orientations for TMs 15, relative to the GLP-1-bound and oxyntomodulin-bound complexes (Fig

These data in conjunction with multiple reports in the 1920s and 1930s that intestinal mucosa had hypoglycemic properties led the authors of both papers to hypothesize that a gut-derived humoral substance contributed to the regulation of insulin secretion (Figure 1)

10.3389/fmicb.2017.02429 Front