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Like other matricellular proteins, it seems likely that TNX interacts with cells through specific receptors

Clemente et al

Lancet 383(9911):3139 Tabernero J et al (2015) Ramucirumab versus placebo in combination with second-line FOLFIRI in patients with metastatic colorectal carcinoma that progressed during or after first-line therapy with bevacizumab, oxaliplatin, and a fluoropyrimidine (RAISE): a randomised, double-blind, multicentre, phase 3 study