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Before being removed by urine, some urobilinogens are reabsorbed into the bloodstream (Fig

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While reports provide some evidence for the involvement of endogenous glutamate in the pathogenesis and treatment of depression[22,50,69,70], the complexity of the disorder would suggest that the dysregulation of glutamate needs to occur in multiple sites (Figure 1) such as the gastrointestinal tract and brain, as can be seen if there is a communication link involving exogenous glutamate, the gut, endogenous glutamate, and then the brain in a multidirectional pathway which we would call the GLUTAMATE-GUT-GLUTAMATE-BRAIN AXIS