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As a result, much of the GLP-1 in intestinal veins is already degraded (46)

Phase 2 trial results showed that people with obesity (BMI 30) but not diabetes lost up to 24% of their initial body weight in 48 weeks when combining weekly retatrutide injections with diet and exercise

When to Consider Resuming or Switching to Different GLP-1 Therapies Some patients find that weight regain occurs despite genuine effort to maintain behavioral changes, particularly those with genetic predispositions toward rapid appetite return or metabolic resistance

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