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This signal specifically suppresses the transcription of CYP7A1, the rate-limiting enzyme in classical bile acid synthesis, thereby preventing bile acid overload and hepatotoxicity (Kuang et al., 2023

Additionally, Interleukin 4 Induced Protein 1 (IL4i1) is an extracellular matrix enzyme that metabolizes tryptophan and its metabolites to regulate the intracellular redox balance (89, 90)

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