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Endocrinology 107:15301535 Talbott SM, Cifuentes M, Dunn MG, Shapses SA (2001) Energy restriction reduces bone density and biomechanical properties in aged female rats

While bolus administration, especially with TZP, was associated with acute weight loss, hydrogel-based formulations mitigated this effect, supporting more stable weight profiles throughout the treatment period ( Figure 5B )

6.2 Potential pathophysiological mechanisms of gut microbiota and metabolite SCFAs in cytokine abnormalities SCFAs (such as acetate, propionate, and butyrate) activate receptors like FFAR2/3 and Gpr109a and inhibit histone deacetylase (HDAC), collectively suppressing the activation of the NF-B signaling pathway, thereby downregulating the expression of pro-inflammatory cytokines (202204)

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