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Pyroptosis is mediated exclusively by gasdermin family proteins (GSDMD, GSDME), whose cleavage by caspases (caspase-1 for canonical, caspase-4/5/11 for noncanonical, caspase-3 for GSDME-dependent pathways) forms plasma membrane pores, leading to cellular swelling, rupture, and release of pro-inflammatory cytokines (IL-1, IL-18)a defining feature that makes pyroptosis the most potently inflammatory of the three pathways (117)