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Local inflammation caused by surgery becomes systemic within 48 h and induces systemic inflammatory response syndrome (SIRS), leading to increased levels of proinflammatory cytokines and neutrophil infiltration and causing tissue and organ damage

2 Impaired iron homeostasis and brain dysfunction Iron is essential for multiple biological functions, including oxygen transport, redox actions, and DNA synthesis (Khn, 2015)

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2.6 Determination of liver function markers The serum alanine aminotransferase (ALT) and aspartate aminotransferase (AST) levels were assessed using commercial kits purchased from Biodiagnostic, Cairo, Egypt as described by Reitman and Frankel (1957)

Evaluation of in vivo cytogenetic toxicity of europium hydroxide nanorods (EHNs) in male and female Swiss albino mice