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Pfizer and OPKO did not state the reasons for the initial denial

Description Overview BPC157 is a synthetic pentadecapeptide (15 amino acids) that comes from a fragment of a larger endogenous gastric protein complex commonly referred to as Body Protection Compound (BPC)

partial sequence of human Body Protection Compound Sequence: H-Gly-Glu-Pro-Pro-Pro-Gly-Lys-Pro-Ala-Asp-Asp-Ala-Gly-Leu-Val-OH (GEPPPGKPADDAGLV) Synonyms: PL 14736, PLD-116 CAS Number: 137525-51-0 Molecular Formula: C 62 H 98 N 16 O 22 Molecular Weight: 1419.55 g/mol Mechanism (working): modulation of nitric oxide system, VEGFR-2 expression, and growth factor signaling supporting GI, vascular, and connective-tissue repair Regulatory status: not approved by the FDA or EMA TB-500 Compound class: synthetic N-acetylated heptapeptide

5:4478 doi: 10.1038/ncomms5478 (2014)

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