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Patients should never discontinue or adjust medications without provider guidance, as abrupt changes can lead to worsening or uncontrolled blood pressure or loss of glycemic control

Figure 1 In addition to the splice variants, GR has eight alternative translation initiation sites in exon 2, arising from leaky ribosomal shunting of the mRNA (20)

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Mol Pharmacol 46:909914 Kim SK, Woodcroft KJ, Khodadadeh SS, Novak RF (2004) Insulin signaling regulates gamma-glutamylcysteine ligase catalytic subunit expression in primary cultured rat hepatocytes

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