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This is why many providers recommend pausing GLP-1 therapy during acute gastroenteritis or severe flu symptoms with vomiting

B., Renstrm, F., Aczl, S., et al

Xultophy 100/3.6 (insulin degludec and liraglutide injection) [package insert]

These findings suggest a potential protective role for GLP-1 signaling in modulating orbital inflammation, though prospective trials are required for confirmation

These variants may help provide context for receptor sensitivity and glucose regulation patterns, supporting a more informed provider conversation about which mechanism to prioritize