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The combination of all three (triple agonism) is the design hypothesis: act on appetite, insulin, and energy burn together, with the molecule tuned to be roughly nine times more active at the GIP receptor than the body's own GIP hormone, and somewhat less strongly active at the other two [2]

doi: 10.3389/fendo.2024.1465881 Received 18 July 2024 Accepted 28 August 2024 Published 20 September 2024 Volume 15 - 2024 Edited by Xiaosheng Tan, Rutgers, United States Reviewed by Xiaodong Zou, The Chinese University of Hong Kong, Shenzhen, China Xue Wan, Mayo Clinic, United States Xun Sun, Indiana University, United States Updates Copyright 2024 Ji, He, Min, Yang, Wu, Xu, Chen and Mei

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