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COX-1 is often thought of as the physiologic housekeeper for many activities including vascular homeostasis, maintenance of renal and gastrointestinal blood flow, renal function, intestinal mucosal proliferation, platelet function, and antithrombogenesis

Ozempic is available in 0.5 mg, 1 mg, and 2 mg dosages, while Mounjaro is available in 2 mg, 12.5 mg, and 15 mg dosages

The second question relates to what was described as perceived excessive weight loss in the extension period of the SURMOUNT-1 study, where dose modifications of the blinded study drug were allowed to support patient management and retention during the additional two-year treatment phase

Separately, another study suggested that longer durations of GLP-1RA treatment may help sustain weight loss even after discontinuation, although this hypothesis remains to be validated