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In particular, combining 2-OHNA with other NAD + biosynthesis inhibitors like FK866 effectively kills NAPRT-proficient cancer cells resistant to single-agent treatments 217

Additionally, the elongated shape of tubular recycling endosomes possibly facilitates more efficient interactions with the cytoskeletal transport machinery, enhancing their capacity for long-distance transport 47

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This means healthcare providers can prescribe them based on a patients unique circumstances, but they are not officially sanctioned for this particular condition.