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Patient was receiving: - Citalopram - Linezolid 600 mg BD High-risk combination leading to serotonin syndrome Additionally: - Domperidone + Ondansetron + SSRI Significant risk of QT interval prolongation Clinical findings: - BP: 180/100 mmHg - Tachycardia - High suspicion of serotonin toxicity + cardiac risk --- Pharmacist intervention: I immediately discussed with the ICU team that increase in BP is due to serotonin syndrome and recommended Hold Citalopram or change to other antidepressant Switch Linezolid Vancomycin or continue just linezolid Review prokinetic/antiemetic therapy due to QT risk For domperidone: Suggested safer alternatives: - Itopride --- Outcome: - Citalopram held - Linezolid switched to Vancomycin - QT-risk drugs optimized - Patients serotonin toxicity risk and cardiovascular instability reduced --- Key learning: Clinical pharmacists play a vital role in ICU by: - Preventing life-threatening drug interactions - Identifying serotonin syndrome early - Managing QT prolongation risks - Supporting rational therapy decisions Small interventions can prevent major adverse drug events

19 Increased heart rate has been noted with Wegovy

Clinical outcomes, including cumulative incidence of complications, were comparable between pathways applying tirzepatide and semaglutide as second- and third-line treatment (Fig

Background of the Invention Dementia There are approximately 10 million diagnosed dementia patients in the United States alone and that number continues to grow every year as the population ages