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Chakravartti SP et al

had taken, within 3 months before visit 2, medications (prescribed or over-the-counter) or alternative remedies that promote weight loss Examples included, but were not limited to Saxenda (liraglutide 3.0 mg) Xenical/Alli (orlistat) Meridia (sibutramine) Acutrim (phenylpropanolamine) Sanorex (mazindol) Apidex (phentermine) BELVIQ (lorcaserin) Bontril (phendimetrazine) Qsymia (phentermine/topiramate combination) Contrave (naltrexone/bupropion) Note: use of metformin, or any other glucose-lowering medication, whether prescribed for polycystic ovarian syndrome or diabetes prevention, was not permitted

Adverse effects are generally limited to gastrointestinal disturbances, which can be managed through dose reduction and caution around anaesthesia

Cellular adhesion molecules including ICAM-1 , VCAM-1 , and ELAM-1 were increased in expression at 20 M and 100 M PAGln (Fig

Autistic disorder in 2 children with mitochondrial disorders