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Aqueous deficiency arises from inadequate tear production, frequently resulting from disorders such as Sjgren's syndrome or failure of the lacrimal glands

ALCAR may also alleviate depression, may be used in the treatment of Parkinsons disease, stroke, and Peyronies disease, and may have a protective effect on the central nervous system and may benefit the heart

MERS-CoV persists in dromedary camels in Middle Eastern countries, causing sporadic outbreaks in humans with limited human-to-human transmission

To further mitigate risk, many studies involve sentinel subjects typically only 1 participant on the active drug and 1 on placebo who receives the investigational drug before the remaining participants in the cohort are dosed

Because we are neither proposing to modify the number of hospitals that will be selected for validation nor the number of records each selected hospital will be required to submit, we are not proposing any changes to our currently approved burden estimates as a result of this proposal