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A GLP-1/glucagon (GCG)/CCK2 receptors tri-agonist provides new therapy for obesity and diabetes

Transforming growth factor 1 (referred to in the figures as the Tgfb1 gene) was not increased in a diabetic setting, but the combination therapy with empagliflozin, semaglutide, and ramipril significantly reduced this profibrotic gene RNA expression ( p = 0.023) (Figure 3H), which correlates with the decreased mesangial matrix deposition in the same group of mice

A pilot study of high-dose interleukin-3 treatment of relapsed follicular small cleaved-cell lymphoma: hematologic, immunologic, and clinical results

And last week, Amazon One Medical jumped into the GLP-1 fray

The orforglipron analysis looks at an oral GLP-1 agonist in development