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In sepsis-induced organ injury, they not only exhibit tissue specificity and functional heterogeneity but also provide potential targets and intervention strategies for ncRNA-based therapies, such as the delivery of protective ncRNAs via exosomes or the use of antagonists to inhibit pathogenic ncRNAs (Ma et al., 2025) (Figure 3) FIGURE 3 3.9 METTL3-mediated N6-methyladenosine N6-methyladenosine (m6A) is the most prevalent and conserved type of internal RNA modification, extensively regulating the functions of various RNAs, such as messenger RNA and long noncoding RNA, at the posttranscriptional level and participating in numerous biological processes (Li Y

Conversely, an SI value below 2 suggests that the pure compound exhibits general toxicity 78

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Pregnancy: During pregnancy, elevated estrogen and progesterone levels can lead to melasma, giving it the nickname mask of pregnancy. Birth Control Pills & Hormone Therapy: Hormonal contraceptives and hormone replacement treatments can also initiate melasma in some individuals

May not address medication options adequately