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Murine features of neurogenesis in the human hippocampus across the lifespan from 0 to 100 years

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Indeed, hormone influence over BDNF expression has been demonstrated in gonadectomized female and male rats, showing decreased BDNF mRNA levels in the hippocampus that can be rescued after estradiol supplementation (Singh et al., 1995

The accumulation of AEGs and their binding to the receptor for glycosylation end-products (RAGE) promotes oxidative stress, which activates the NF-B signalling pathway, upregulates the expression of target genes and triggers inflammation (22)

Key mechanisms include: Activation of neurons in the area postrema and nucleus tractus solitarius in the brainstem Enhanced satiety signaling through distinct pathways from GLP-1 mechanisms Slowed gastric emptying via calcitonin receptor-mediated effects Reduced food reward signaling and decreased food noise through central appetite centers Studies in knockout mouse models confirmed that cagrilintides weight loss effects depend specifically on AMY1R and AMY3R presence, demonstrating receptor-specific mechanisms