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Plasma protein binding properties and accumulation potential Following intravenous injection into the systemic circulation, platinum-based agents form irreversible covalent bonds with plasma biomacromolecules within minutes to hours, predominantly with HSA

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Author information Authors and Affiliations Centre for Genome Engineering and Maintenance, Division of Biosciences, Department of Life Sciences, College of Health and Life Sciences, Brunel University London, Uxbridge, UB8 3PH, UK Sarah Al-dulaimi, Ross Thomas & Terry Roberts Respiratory Clinical Research Facility, Royal Brompton Hospital, Fulham Road, London, SW3 6HP, UK Sheila Matta Authors Sarah Al-dulaimi Ross Thomas Sheila Matta Terry Roberts Corresponding author Correspondence to Terry Roberts

Cheng JB, Zhu J, Ni F, Jiang H