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and (3) early oxyntomodulin analogs, which were discontinued in part because regulatory endpoints for combination receptor agonism had not yet been established (Weyer et al., 2001

in a landmark 1998 European Journal of Endocrinology paper as the first selective growth hormone secretagogue

Most research suggests cumulative exposure over time is more important than precise timing

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Back Moore, B, Edie, ES, Abram, JH (1 Jan 1906) 'Further observations on the treatment of diabetes mellitus by acid extract of duodenal mucous membrane', Biochemical Journal , 1/9-9, 446-54