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CKD results in impaired GHR and GH signaling characterized by an altered GH-induced hepatic, as well as growth plate cartilage IGF-1 synthesis, due to a reduced expression of the GHR and/or a postreceptor signaling defect [156,157,158]

We prioritized evidence derived from human clinical trials, placing a distinct emphasis on randomized controlled trials (RCTs) and comprehensive systematic reviews published from 2015 onwards, reflecting the most recent and rigorous advancements in the field