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Nature 418 (6898), 650654

Adapting to Oral GLP-1 Concerns The regulatory themes highlighted in the compounded spaceaccuracy in claims, proper oversight, and clear labelingare equally relevant to oral GLP1 options

GLP-1R-dependent signaling is essential for the CNTF-induced cell proliferation, evidenced by the increased expression of GLP-1 in the hypothalamus of mice and the lack of efficacy in GLP-1R knockout mice