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14 Beyond the stimulation of glucose-dependent insulin secretion from the pancreas, GLP-1 also controls glycemia by inhibiting food intake, glucagon secretion, gastric emptying, and possesses protective actions in pancreatic beta cells including survival, proliferation, and biosynthesis of the insulin precursor, proinsulin

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Int J Pharm 624:121842121842 Bendicho-Lavilla C, Seoane-Viao I, Otero-Espinar FJ, Luzardo-lvarez A (2022) Fighting type 2 diabetes: formulation strategies for peptide-based therapeutics

The same molecule produces the same GI profile (nausea, vomiting, diarrhea, constipation), the same satiety effect, and the same thyroid C-cell rodent warning

We can conclude that directly reversing the metabolism of the failing heart back to fatty acid oxidation as a substrate for myocardial energy may instead be detrimental to cardiac function