PMEPA1 Polyclonal Antibody, 20ul Yeast Expression Several alternatively spliced transcript variants

Several alternatively spliced transcript variants of DMPK have been described

8 Adapters

Cyclin D1 has been shown to interact with tumor suppressor protein Rb and the expression of this gene is regulated positively by Rb

Down-regulation of the encoded protein in hepatocellular carcinoma was associated with large tumor size and poor patient survival rates

It involves in translation termination in response to the termination codons UAA

PMEPA1 Polyclonal Antibody, 20ul Yeast Expression Several alternatively spliced transcript variantsPMEPA1 encodes a transmembrane protein that contains a Smad interacting motif (SIM). Expression of PMEPA1 is induced by androgens and transforming growth factor beta, and the encoded protein suppresses the androgen receptor and transforming growth factor beta signaling pathways though interactions with Smad proteins. Overexpression of PMEPA1 may play a role in multiple types of cancer. Alternatively spliced transcript variants encoding multiple